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Pichler 1G. Djedovic 2V. Hauser 1E. Richter 3H. Fritsch 3G. Klinglmair 1H. Klocker 1R. Müller 1Prostatavolumen Uhr. Radmayr 1W. Horninger 1J. Introduction and Objectives Identifiable causes of hypospadias are still infrequently well known.

The aim of this study was to quantify and to compare the androgen receptor AR mRNA and androgen receptor protein in prepuces of boys with and without hypospadias. Material and Methods 40 prepuce specimens of circumcised boys 20 with Prostatavolumen Uhr 20 without Prostatavolumen Uhr were enrolled in this prospective study.

Mean age was Results Our observations show that the androgen receptor mRNA was significantly elevated in the prepuce of hypospadiac boys compared to specimens of boys with phimosis Also the amount of androgen receptor protein was higher in comparison to healthy boys These results provide evidence that the raise of androgen receptor mRNA and protein seems to be an indirect expression of decreased androgen receptor DNA binding capability possibly indicating further missing Prostatavolumen Uhr encoding.

Conclusions Our results lead us to say that the different expression of androgen receptor mRNA indicates the extent of a defect androgen receptor AR signalling in boys with hypospadias. Herkommer, E. DonelS. Heister, J. Gschwend, M. Purpose Little is known about familial clustering of fatal prostate cancer pc and an association between Prostatavolumen Uhr family history FHapparent mode of disease transmission, and survival.

The aim of this study was to determine the impact of a fatal FH and the apparent mode of disease transmission on survival of prostate cancer patients after radical prostatectomy in Germany. Material and Methods patients after radical prostatectomy with at least one first-degree relative with pc of the nationwide database familial pc in Germany were stratified according to 1 family history fatal Prostatavolumen Uhr non-fatal and 2 apparent mode of disease transmission male to male vs Prostatavolumen Uhr to male.

Biochemical progression-free survival BPFSoverall survival OSand cancer-specific survival CSS for each epidemiological feature were analyzed according to the method of Kaplan and Meier and subgroups were compared in a proportional hazard regression calculating hazard ratio HR and p-value.

Results In the subgroup with fatal pc we observed less organ-confined tumours In the Prostatavolumen Uhr with male-to-male transmission we observed more patients with a fatal FH Conclusion Survival was not remarkably different in familial patients with fatal family history compared to those with non-fatal FH. Our findings suggest that fatal FH and the apparent mode of disease transmission are not associated with poorer survival and worse clinical outcome.

Herkommer, H. Schulwitz, T. KlorekS. Schmid, C. Hofer, J. Introduction and Objectives It is still under question if older patients and patients with comorbidities have a worse QoL. Therefore, the aim was to evaluate health-related quality of life depending on age at radical retropubic prostatectomy RRP and Prostatavolumen Uhr.

Subgroups according to age at diagnosis? Subgroups were compared using the Wilcoxon-Mann-Whitney Prostatavolumen Uhr while comp arisons within a group over time were done with the Wilcoxon signed rank test. Results A total of patients were included in this study. Emotional functioning improved during the first 12 months Emotional functioning before RRP was better in patients? Social functioning also was better in patients? Global health, physical, role, cognitive and social functioning were independent of the number of comorbidities.

Conclusion Emotional functioning improves after RRP. In all other function scores and Prostatavolumen Uhr global health score, 12 months after RRP quality of life is comparable to the preoperative status. Especially Prostatavolumen Uhr of older patients is not influenced Prostatavolumen Uhr through RRP, amazingly patients older than 70 years have higher scores for emotional and social functioning compared to younger patients and comparable scores for physical, role, cognitive functioning, and global health.

Surprisingly quality of life was independent of the number of comorbidities. Bründl 1S. Schneider 1F. Zeman 2W. Wieland 1R. Introduction Beyond the accepted routes of hematogenous as well as lymphatic spread, perineural invasion PNI is discussed as a significant route of extracapsular extension in prostate cancer PC.

Recent in-vitro studies suggested a complex mechanism of Prostatavolumen Uhr interaction. Material and Methods Whole mount sections of the prostate were created from patients undergoing non-nerve-sparing laparoscopic radical prostatectomy with wide excision of the neurovascular bundle. Of each prostate, adjacent sections out of one representative area were chosen and stained to identify capsular nerves S as well as to localize cancer foci HE.

For statistical analyses mixed linear models were calculated using SAS 9. Results Specimens of 33 patients were available for analysis.

Prostatavolumen Uhr total number of capsular nerves and a total capsular nerve surface area ofpixel 2 respectively were analysed. The major proportion was found Prostatavolumen Uhr the dorsolateral position.

Tumour infestation was associated with a statistically significant higher overall capsular nerve count compared to the corresponding contralateral tumour-free sectors 3. Similar results were shown for overall capsular nerve surface area Conclusion This is the first study investigating a quantitative relation of capsular nerves of the Prostatavolumen Uhr in relation to adjacent cancer foci. Prostatavolumen Uhr of PC foci resulted in significantly increased overall capsular nerve count and capsular nerve surface area compared to corresponding tumour-free sectors.

The present study supports former in-vitro findings suggesting that extracapsular extension by PNI is based on complex neuroepithelial interactions resulting in prostate cancer-induced nerve growth. There is a need for further studies to identify the exact underlying mechanism in order to study the option of future targeted therapeutic approaches.

HatzichristodoulouM. Heck, S. Wagenpfeil, K. Kübler, J. However, limited data exists on this issue. We present data of Prostatavolumen Uhr series of patients. An IIEF-5? Pre- and postoperative EF data was available in all patients. Results From December to Januarypatients were included Prostatavolumen Uhr this study. Prostatavolumen Uhr patient age was Mean number of removed lymph nodes were At a mean follow-up of HerlemannF.

Strittmatter, C. Stief, C. Over a time frame of 12 weeks, 18 members of our department completed various teaching and practicing modules. Basic demographic data, clinical experience, and various motor skills such as playing a musical instrument and video games were assessed. However, the intensity of playing v ideo games did not correlate with the ability to score at the GL SIM.

The scores obtained for participants of different training levels correlated well with clinical Prostatavolumen Uhr. While a history of playing video games did not correlate with the ability to perform at the GL SIM, playing a musical instrument improved the outcome at the simulator. KretschmerC. Stief, R. Introduction and Objectives The transobturator retroluminal repositional sling suspension was first introduced in for the treatment of male stress urinary incontinence SUI.

Besides other innovations, its sling arm length Prostatavolumen Uhr been increased Prostatavolumen Uhr better accommodate with a greater body mass index BMI and anchors were added to improve capability in the early postoperative period to reduce early failure due to sling loosening or sling slippage. Pad use was evaluated after 3 months and maximum follow-up.

Additionally, adverse events AE were classified. Prostatavolumen Uhr 3 months, At maximum follow-up In contrast, statistical analysis of the obese and normal weight patients showed no statistical differences after 3 months as well as after maximum follow-up.

Prostatavolumen Uhr of AE revealed Conclusions In the longer-term follow-up, AdVance XP shows statistically significant better results in Prostatavolumen Uhr patients. In our cohort, no statistical benefit could be proven for normal weight and obese patients.

One might speculate that patients with a BMI of