Benign Prostatic Hyperplasia
Purpose: This study will use PET scans, which is a type of x-ray test that uses a radiotracer, to see whether these scans may be better able to find places in the body where your prostate cancer may have spread.
View trial on ClinicalTrials. Purpose: Objectives: The objectives BPH Chirurgie Saratov this study are to: 1 evaluate the feasibility of 3T MRSI of prostate in improving the spectral resolution, using a PFC-filled endorectal coil, 2 develop a systematic metabolic grading system for tumor BPH Chirurgie Saratov by identifying the abnormal peak areas of Cho, Cr, Po, and Ci for the prostate carcinoma, specifically from PFC-filled endorectal 3T MRSI, and 3 evaluate the efficacy of the metabolic grading system in tumor detection.
The long-term BPH Chirurgie Saratov of the study is to provide an early prognostic indicator and means of BPH Chirurgie Saratov the biologic status of the prostate cancer during the course of the disease. Purpose: The goal of this behavioral research study is to look at patients' quality of life after treatment or management for prostate cancer. Purpose: The purpose of this study is see if quality of life is improved in patients receiving oral hormone therapy compared to standard of care.
The study will also compare survival rates between patients receiving oral hormone therapy and those receiving standard of care. Purpose: A study to evaluate the safety and initial effectiveness of the ExAblate Conformal Bone System in the treatment of pain resulting from metastatic bone tumors. The safety of this drug will also be studied. Purpose: This study is a multi-centre, prospective observational study. Purpose: The purpose of this study is to document prostate cancer PC management including diagnosis, prognosis, treatment, and care in real-world practice.
Purpose: The purpose of this study is to assess the safety and efficacy of enzalutamide in patients with non metastatic prostate cancer. Purpose: The purpose of this study is to assess the safety and efficacy of BAY ODM in patients with non-metastatic castration-resistant prostate cancer.
BPH Chirurgie Saratov This trial is designed as a randomized two-arm LDE vs. The investigators propose to determine the effects of LDE on neoplastic prostate tissue from men at high risk of systemic disease progression, by comparing pre-surgical core-biopsy specimens to tumor tissue harvested at the time of prostatectomy.
Purpose: The purpose of this study is to evaluate the safety of MGA when given by intravenous IV infusion to patients with refractory cancer. The study will also evaluate how long MGA stays in the blood and how long it takes for it BPH Chirurgie Saratov leave the body, what is the highest dose that can safely be given, and whether it may have an effect on tumors.
Purpose: The objective of this study is to determine if systemically infused allogeneic bone marrow derived mesenchymal stem cells MSC home to sites of prostate cancer in men with localized adenocarcinoma of BPH Chirurgie Saratov prostate that are planning to BPH Chirurgie Saratov a prostatectomy. Investigators plan to systemically infuse MSCs 4, 6 or 8 days prior to enrolled subjects' planned prostatectomies. This trial will provide the foundation for future studies aimed at engineering MSCs to deliver a toxin to sites of metastatic prostate cancer.
Purpose: The purpose of this study is to test a novel diagnostic Positron Emission Tomography PET imaging agent for safety and biodistribution. Purpose: Patients with localised prostate cancer can be treated by radical prostatectomy prostate gland removal surgery or radiotherapy. To date little progress has been made towards identifying effective treatment strategies that might delay or prevent disease recurrence in this patient population.
Better identification of patients at high risk of relapse and improvements in therapy are therefore research priorities. A protein named Mammalian Target of Rapamycin mTOR is known to play an important role in the development of prostate cancer. Blocking the function of mTOR, with an inhibitor such as AZD, might shut down the supply of energy supply to tumour cells leading to reduced cell growth and potentially slowing the progression of the disease.
The purpose of this study is to investigate the molecular pharmacology of AZD treatment given to patients with prostate cancer prior to radical prostatectomy. The feasibility, safety and tolerability of a short course of AZD will also be assessed.
Purpose: This is a single centre prospective observational noninterventional study BPH Chirurgie Saratov men with histological confirmed prostate cancer, high risk disease and not positive for metastatic disease planned to receive Radiotherapy and 18 months of Androgen Deprivation Therapy ADT. Although ADT improves the chance of cure, it can also have many side effects. One of BPH Chirurgie Saratov is bone mineral density loss.
When this is advanced, it is called osteoporosis. Men with osteoporosis have a higher chance of getting fractures of bones such as the hip and spine. Currently, the best way to measure for osteoporosis is to do a bone mineral density scan using a DEXA scanner. The data from the patients will be used to construct a model predicting annual rate of bone loss based on baseline imaging, BPH Chirurgie Saratov and biochemical characteristics. Usually, ADT is given for between 19 months before radiotherapy is started but there is no agreement as to which duration is best.
This is a blood test which can BPH Chirurgie Saratov cancer cells in the blood which has been used for patients with metastatic cancer. The presence of CTCs in men with prostate cancer correlated with poorer overall survival.
Potentially, high risk prostate cancer patients with CTCs detected may represent a very high risk group and could therefore warrant treatment intensification.
Measuring bone marrow may help in predicting not just which patients are at risk of losing bone faster but also of becoming anaemic, and suffering fatigue. A correlation may better explain some of the toxicities associated with ADT.
This trial aims to use a decision making tool called a nomogram BPH Chirurgie Saratov help tailor the area to treat in a more standard way. Purpose: The purpose of this study is to determine whether Nivolumab plus Ipilimumab has preliminary evidence of safety and BPH Chirurgie Saratov in the treatment of participants with metastatic castration-resistant prostate cancer who have progressed after prior Docetaxel-containing regimen.
Purpose: The aim of this study is to test BPH Chirurgie Saratov safety and efficacy of Stereotactic Body Radiation Therapy SBRT in localized prostate carcinoma in patients for whom the standard treatment is the irradiation of the entire prostate BPH Chirurgie Saratov with or without seminal vesicles accompanied or not by hormonal therapy.
In light of the accumulating clinical evidence favoring the use of hypo fractionation, SBRT regimen might constitute a much more convenient non-invasive and highly efficient outpatient therapy. In the phase 1 portion, the safety of the combination dosing will be determined. If BPH Chirurgie Saratov combination dosing is determined to be safe and feasible, BPH Chirurgie Saratov study will move onto phase 2a. In the phase 2a portion, participants will be randomized to receive either: rucaparib alone, nivolumab alone, or combination therapy rucaparib and nivolumab.
Purpose: Hypofractionated regimen in high-risk prostate cancer will allow the investigators to deliver higher biological doses to targets in order to improve tumor control and with acceptable rectal toxicity compared to BPH Chirurgie Saratov fractionation.
BPH Chirurgie Saratov has many advantages over LDRB such as prospective dosimetry not impacted by setup errors, organ motion and prostate swelling during treatment delivery. Acute urinary retention can BPH Chirurgie Saratov to prolonged catheterization, pericatheter urine leakage, urinary tract infection and Trans-Urethral Resection of the Prostate resulting in diminished quality of life QOL and increased psychological distress.
The absolute PSA nadir and a prostate biopsy at 36 months will be reported to assess local BPH Chirurgie Saratov. Purpose: This randomized phase II trial will evaluate BPH Chirurgie Saratov a low-fat diet with fish oil has the potential to delay disease progression in patients with prostate cancer undergoing active surveillance. BPH Chirurgie Saratov study is being done because there are unmet medical needs to improve the current ways of detecting prostate cancers before surgery.
Purpose: The purpose of this study is to look at patient outcomes when BPH Chirurgie Saratov is started prior to ADT with degarelix. Purpose: The purpose of this study is to find out the effects of giving durvalumab alone or in combination with tremelimumab on this type of cancer. In addition, this study will look at the side effects of durvalumab when given alone or in combination with tremelimumab.
Purpose: This is BPH Chirurgie Saratov study to first establish feasibility of the study and then to register the treatment data of adult patients with a diagnosis of intermediate risk of prostate cancer presenting for definitive radiation treatment with either proton radiotherapy or Intensity Modulated Radiation Therapy IMRT.
The investigators propose to employ a hypofractionated strategy with our image guided treatment to further improve cancer control and decrease toxicity. Purpose: Some men newly diagnosed with prostate cancer do not require immediate treatment. Rather, they can be followed closely with regular physical exams, blood work and repeated biopsies of the prostate.
If the prostate BPH Chirurgie Saratov is becoming more aggressive, curative treatment can be offered at that time. This strategy of delaying treatment until necessary is called active surveillance in prostate cancer. Active surveillance is a way of monitoring prostate cancer which aims to avoid or delay unnecessary treatment in men with less aggressive cancer. Prostate BPH Chirurgie Saratov can be slow growing and, for many men, the disease may never progress or cause any symptoms.
In other words, many men with prostate cancer will never need any treatment. Treatments for prostate cancer may cause side effects which can affect your quality of life. By monitoring the cancer with regular tests, you can avoid or delay these side effects. Active surveillance is generally suitable for men with low risk early stage prostate cancer that is contained within the prostate gland localized prostate cancer.
If doctors had a better way of identifying who might be best suited for this approach, it would likely become more appealing for more men.
In this study, the investigators are looking at how accurate a magnetic resonance imaging MRI scan is at identifying high-risk prostate cancer, which might make a man a poor candidate for active surveillance. To do this, the investigators are collecting data from the MRI scan of men and comparing it to a trans-rectal biopsy performed following the scan. The results of this study will help inform doctors how accurate the MRI is in identifying men who should not be BPH Chirurgie Saratov active surveillance.
BPH Chirurgie Saratov This randomized phase II trial studies pomegranate-extract pill in preventing tumor growth in patients with prostate cancer that is limited to a certain part of the body localizedwho have chosen observation as their treatment plan.
The use of pomegranate-extract pill may slow disease progression in patients with localized prostate cancer. Observe the incidence of GI and GU BPH Chirurgie Saratov.
Purpose: 1. The investigators hypothesize that increasing radiation dose to the functional MRI-defined lesion in the prostate bed will result in an improved initial complete response reduction in prostate-specific antigen PSA to View trial on ClinicalTrials.
Delivery of directed hypofractionated targeted BPH Chirurgie Saratov radiotherapy RT tumor boost to the dominant tumor lesion BPH Chirurgie Saratov the prostate as identified by multiparametric MRI will increase tumor eradication from the prostate. Biomarker expression levels differ in the multiparametric MRI defined regions at high risk of harboring tumors that determine outcome. Quality of life will not differ significantly between the treatment arms. Prostate cancer-related anxiety will be reduced in the HTIMRT arm, because the patients will be aware that the dominant tumor will be targeted with higher radiation dose.
Purpose: This Phase III, multicenter, BPH Chirurgie Saratov, open-label study will evaluate the safety and efficacy of atezolizumab anti-programmed death-ligand 1 [anti-PD-L1] antibody in combination with enzalutamide compared with enzalutamide alone in participants with mCRPC after failure of an androgen synthesis inhibitor e.
Participants will be randomized to one BPH Chirurgie Saratov the two treatment arms atezolizumab in combination with enzalutamide, and enzalutamide alone in a ratio experimental to control arm in global randomized phase.
Participants will receive treatment until investigator-assessed confirmed radiographic disease progression per Prostate Cancer Working Group BPH Chirurgie Saratov PCWG3 criteria or unacceptable toxicity. Purpose: This phase I trial studies the side effects of daratumumab or FMS inhibitor JNJ before surgery in BPH Chirurgie Saratov patients with high-risk prostate cancer that can be removed by surgery and has not spread to other parts of the body or has spread BPH Chirurgie Saratov nearby tissue or lymph nodes.
Immunotherapy with monoclonal antibodies, such as daratumumab, may help the body's immune system attack the cancer, and may BPH Chirurgie Saratov with the ability of tumor cells to grow and spreadFMS inhibitor JNJ may BPH Chirurgie Saratov the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Giving daratumumab or FMS inhibitor JNJ before surgery may work better in treating patients with prostate cancer. Purpose: The purpose of this study is to examine whether psychoeducation counseling for older cancer patients undergoing treatment is feasible BPH Chirurgie Saratov worthwhile. The investigators will test this in a group or individual phone counseling format. Many cancer patients seek counseling to help with the emotional burden of their illnesses.
Counseling often helps them cope with BPH Chirurgie Saratov by giving them a BPH Chirurgie Saratov to express BPH Chirurgie Saratov feelings. This geriatric-specific psychoeducation is intended to help older cancer patients cope with the burden of cancer and aging.
The purpose of this study is to see if this type of counseling helps reduce depressive symptoms, anxiety, perception of loneliness and isolation. In addition this counseling aims to improve coping and quality of life QOL. Individuals who choose not to take BPH Chirurgie Saratov in the intervention study BPH Chirurgie Saratov be asked if they are willing to participate in a brief refusal sub study. The purpose of the refusal substudy is to compare levels of distress in patients that choose to participate and those that decline.
This will yield valuable data that will help us distinguish between patients that decline due to lack of interest in research and those that decline due to high levels of distress. Participation in the refusal sub study consists of completion of 2 brief questionnaires.