Pentoxifyllinealso known as oxpentifyllineis a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease.
Its primary use in medicine is to reduce pain, cramping, numbness, Trental 400 Prostatitis weakness in the arms or legs which occurs due to intermittent claudicationa form of muscle pain resulting from peripheral artery diseases. Pentoxifylline has also been shown Trental 400 Prostatitis be of benefit in alcoholic hepatitis, with some studies demonstrating a reduction in risk of hepatorenal syndrome.
Common side effects are belching, bloating, stomach discomfort or upset, nausea, vomiting, indigestiondizziness, and flushing. Uncommon and rare side effects include angina, palpitations, hypersensitivity, itchinessrash, hivesbleeding, hallucinations, arrhythmias, and aseptic meningitis. Contraindications include intolerance to pentoxifylline or other xanthine derivatives, recent retinal or cerebral haemorrhage, and risk factors for haemorrhage. Like other methylated xanthine derivativespentoxifylline is a competitive nonselective phosphodiesterase Trental 400 Prostatitis  which raises intracellular cAMPactivates PKAinhibits TNF   and leukotriene  synthesis, and reduces inflammation and innate immunity.
There is some evidence that pentoxifyllinenon can lower the levels of some biomarkers in non-alcoholic steatohepatitis but evidence is insufficient to determine if the drug is safe and effective for this use. Pentoxifylline, in combination with tocopherol and clodronatehas been found to heal refractory osteoradionecrosis Trental 400 Prostatitis the jaw,  and to be prophylactic against osteoradionecrosis.
In a Cochrane systematic review on the use of Pentoxifylline for intermittent claudication inthe following was concluded "The quality of included studies was generally low, and very large variability between studies was noted in reported findings Trental 400 Prostatitis duration of trials, doses of pentoxifylline and distances participants could walk at the start of trials.
Most included studies did not report on randomisation techniques or how treatment allocation was concealed, did not provide adequate information to Trental 400 Prostatitis judgement of selective reporting and did not report blinding of outcome assessors. Given all these factors, the Trental 400 Prostatitis of pentoxifylline in intermittent claudication remains uncertain, although this medication was generally well tolerated by participants".
From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. TGA eBusiness Services. Retrieved 3 February Medscape Reference. The Cochrane Database of Systematic Reviews. Apotex Corp. February Clinical guideline No. Scottish Intercollegiate Guidelines Network. Trental 400 Prostatitis Database of Systematic Reviews. The Journal of Allergy and Clinical Immunology. Journal of Immunology. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy".
Current Diabetes Reviews. Lipids in Health and Disease. Current Drug Targets. May Acta Oto-Laryngologica. Arab Journal of Urology. Prophylactic use of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of the head and neck. British Journal of Oral and Maxillofacial Surgery, 54 5pp.
Peripheral vasodilators C Isoxsuprine Buphenine Bamethan. Niacin Nicotinyl alcohol Inositol nicotinate Ciclonicate. Pentifylline Xantinol nicotinate Pentoxifylline Etofylline nicotinate. Ergoloid Nicergoline Dihydroergocristine. Phosphodiesterase inhibitors. BAY PF Purine receptor modulators. Agonists: 8-Aminoadenine Adenine. Hidden categories: Template:drugs. Namespaces Article Talk. Views Read Edit View history.
Many names worldwide . Hepatic and via erythrocytes. P0 adenine Agonists: 8-Aminoadenine Adenine.