Hämostase und Prostata

Vergrösserte Prostata ohne Operation behandeln (Prostata Embolisation)

Prostata als Ersatz

The basic proteinase inhibitor from bovine organs, aprotinin, was first identified in and its effect on enzyme and other biological systems has since been extensively studied.

Aprotinin can only be administered intravenously and has a half-life of about 2 hours. Its administration at the start of cardiopulmonary bypass surgery appears to reduce blood loss and to protect against global myocardial ischaemia. Similarly, a smaller infarct size seems to result from early administration of aprotinin within the first hour after myocardial infarction, though further studies are needed to Hämostase und Prostata this effect.

A combination of aprotinin with tranexamic acid may be effective in preventing Hämostase und Prostata delaying rebleeding after rupture of an intracerebral aneurysm; the Hämostase und Prostata of aprotinin seems to decrease the incidence of delayed cerebral vasospasm and ischaemic complications which are sometimes Hämostase und Prostata when tranexamic acid alone is used.

Aprotinin is also effective as adjuvant treatment in traumatic haemorrhagic shock. Side effects of aprotinin are very rare. Saturation of the lysine binding Hämostase und Prostata of plasminogen with these inhibitors displaces plasminogen from the fibrin surface. All 3 compounds are readily absorbed from the gastrointestinal tract and excreted in active form in the urine.

The plasma half-life of tranexamic acid is about 80 minutes. The main indications for tranexamic acid are the prevention of excessive bleeding after tonsillectomy, prostatic surgery, and cervical conisation, and primary Hämostase und Prostata IUD-induced menorrhagia. It is possible that gastric and intestinal bleeding can also be reduced as well as recurrent epistaxis.

Tranexamic acid could also be useful after ocular trauma. The value of fibrinolysis inhibitors in the prevention of bleeding after tooth extraction in patients with haemophilia is well documented, as is the treatment of hereditary angioneurotic oedema. The usual dose of tranexamic acid is 0. This dose needs to be reduced in patients with renal insufficiency.

The main side effects of tranexamic acid are nausea or diarrhoea. Unable to display preview. Download preview Hämostase und Prostata. Skip to main content. Advertisement Hide. Clinical Application of Inhibitors of Fibrinolysis. Authors Authors and affiliations M. Review Article First Online: 09 November This process is experimental and the keywords may be updated as the learning algorithm improves.

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